Across TCGA patient cohorts, ERI2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERI2-associated genes across cancer lineages are PCNA, Cyclin-B1, and Di-Ras3. Each is linked with ERI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERI2-to-partner and partner-to-ERI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERI2→partner) and Y-score (partner→ERI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.252	+2.415	.001	.003	3	2
UCEC	Cyclin-B1 →	+0.641	+3.459	.001	.005	3	2
UCEC	Di-Ras3 →	-0.123	-2.321	.021	.001	3	2
UCEC	EGFR_pY1068 →	-0.292	-2.807	.001	<.001	3	1
UCEC	HER2_pY1248 →	-0.194	-2.807	.043	<.001	3	1
UCEC	IGFBP2 →	-0.652	-1.874	.005	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

ERI2 survival (RNA) · tumor vs normal (RNA) · all ERI2 data types