Across TCGA cell cohorts, ERI2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERI2-associated genes across cancer lineages are ACOD1, PPP1R17, and TAS2R8. Each is linked with ERI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERI2-to-partner and partner-to-ERI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERI2→partner) and Y-score (partner→ERI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ACOD1 →	+0.007	+4.108	<.001	.005	3	1
LARGE_INTESTINE	PPP1R17 →	+0.039	+3.882	.008	.001	3	1
LARGE_INTESTINE	TAS2R8 →	+0.030	+4.115	<.001	.001	3	1
LARGE_INTESTINE	OR4F5 →	+0.018	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

ERI2 survival (RNA) · tumor vs normal (RNA) · all ERI2 data types