ERI1

Across TCGA patient cohorts, ERI1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERI1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Src_pY527, and EGFR_pY1068. Each is linked with ERI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERI1-to-partner and partner-to-ERI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by ERI1-low versus ERI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERI1→partner) and Y-score (partner→ERI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.833	-3.169	<.001	.019	3	2
UCEC	Src_pY527 →	-0.496	-2.990	.028	.036	3	2
UCEC	EGFR_pY1068 →	-0.322	-3.321	.014	.010	3	1
UCEC	PCNA →	+0.374	+3.169	<.001	.018	3	1
UCEC	Shc_pY317 →	-0.200	-3.000	.012	.036	3	1
UCEC	STAT3_pY705 →	-0.551	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

p38-MAPK_pT180_Y182 by ERI1 expression — UCEC

Explore this box plot interactively →