ERI1

Across TCGA cell cohorts, ERI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,755 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERI1-associated GO terms across cancer lineages are Regulation of regulatory ncRNA-mediated heterochromatin formation, Negative regulation of regulatory ncRNA-mediated heterochromatin formation, and Negative regulation of heterochromatin organization. Each is linked with ERI1 in more than 19 cancer types. Because this analysis shows association rather than direction, both ERI1-to-partner and partner-to-ERI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of regulatory ncRNA-mediated heterochromatin formation grouped by ERI1-low versus ERI1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERI1→partner) and Y-score (partner→ERI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.165	+1.199	<.001	<.001	3	20
BONE	Negative regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.165	+1.199	<.001	<.001	3	20
BLOOD_Myeloma	Negative regulation of heterochromatin organization →	+0.136	+1.225	.001	<.001	3	16
BLOOD_Myeloma	Negative regulation of heterochromatin formation →	+0.136	+1.225	.001	<.001	3	16
BLOOD_Lymphoma	Negative regulation of chromatin organization →	+0.115	+1.385	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA synthesis involved in DNA repair →	+0.080	+0.897	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,755 associations by consensus.

Regulation of regulatory ncRNA-mediated heterochromatin formation by ERI1 expression — BONE

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