ERH

Across TCGA pan-cancer cohorts, ERH mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ERH’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ERH mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ERH is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where ERH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.492	<.001	11	view →
HNSC	Male	IV	+0.383	<.001	11	view →
LSCC	Male	All	+0.560	<.001	9	view →
LUAD	Male	All	+0.463	<.001	9	view →
PDAC	Female	II,III,IV	+0.847	<.001	6	view →
CCRCC	All	All	−0.130	.001	4	view →
OV	All	All	+0.742	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ERH–COAD

Open the COAD breakdown →