ERGIC3

Across TCGA patient cohorts, ERGIC3 protein abundance is significantly associated with the RNA expression of many other genes, with 12,969 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ERGIC3-associated genes across cancer lineages are TNXB, ERGIC2, and TMOD1. Each is linked with ERGIC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both ERGIC3-to-partner and partner-to-ERGIC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERGIC3 versus TNXB in CCRCC, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERGIC3→partner) and Y-score (partner→ERGIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNXB →	-0.950	-0.454	<.001	<.001	3	7
OV	ERGIC2 →	+0.560	+0.416	<.001	<.001	3	6
HNSC	TMOD1 →	-0.910	-0.271	<.001	<.001	3	5
HNSC	TRMO →	-0.426	-0.242	<.001	.006	3	5
OV	N4BP2L1 →	-0.754	-0.566	<.001	<.001	3	5
BRCA	RAB33B →	-0.511	-0.380	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,969 associations by consensus.

ERGIC3 vs TNXB — CCRCC

Explore this scatter interactively →