ERGIC3

Across TCGA cell cohorts, ERGIC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,687 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ERGIC3-associated GO terms across cancer lineages are Attachment of GPI anchor to protein, Response to topologically incorrect protein, and Response to unfolded protein. Each is linked with ERGIC3 in more than 14 cancer types. Because this analysis shows association rather than direction, both ERGIC3-to-partner and partner-to-ERGIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Attachment of GPI anchor to protein grouped by ERGIC3-low versus ERGIC3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERGIC3→partner) and Y-score (partner→ERGIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Attachment of GPI anchor to protein →	+0.134	+0.623	<.001	<.001	3	15
PANCREAS	Response to topologically incorrect protein →	+0.092	+0.495	.002	<.001	2	14
PANCREAS	Response to unfolded protein →	+0.104	+0.416	.001	<.001	2	13
PANCREAS	Endoplasmic reticulum unfolded protein response →	+0.097	+0.307	.001	.003	3	12
BONE	Positive regulation of retrograde protein transport, ER to cytosol →	+0.121	+0.496	.004	.008	2	12
LUNG_NSCLC_LUSC	Protein targeting to vacuole involved in autophagy →	+0.182	+0.618	<.001	.006	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,687 associations by consensus.

Attachment of GPI anchor to protein by ERGIC3 expression — CNS

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