ERGIC3

Across TCGA cell cohorts, ERGIC3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERGIC3-associated genes across cancer lineages are CABP2, OR10G7, and BPIFB3. Each is linked with ERGIC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERGIC3-to-partner and partner-to-ERGIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP2 grouped by ERGIC3-low versus ERGIC3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERGIC3→partner) and Y-score (partner→ERGIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CABP2 →	+0.071	+5.029	<.001	.006	3	1
LUNG_SCLC	OR10G7 →	+0.015	+5.029	.007	.006	3	1
LUNG_SCLC	BPIFB3 →	+0.156	+5.029	<.001	.006	3	1
BLOOD_Leukemia	ASZ1 →	+0.132	+4.152	<.001	.009	3	1
BLOOD_Leukemia	TACR3 →	+0.035	+5.060	<.001	.001	3	1
BLOOD_Leukemia	OR10T2 →	+0.743	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CABP2 by ERGIC3 expression — LUNG_SCLC

Explore this box plot interactively →