ERGIC2

Across TCGA patient cohorts, ERGIC2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERGIC2-associated genes across cancer lineages are MEK1, MSH2, and MSH6. Each is linked with ERGIC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERGIC2-to-partner and partner-to-ERGIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ERGIC2-low versus ERGIC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERGIC2→partner) and Y-score (partner→ERGIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.377	+2.584	.027	.011	3	1
UCEC	MSH2 →	-0.273	-2.973	.011	.035	3	1
UCEC	MSH6 →	-0.362	-3.169	.018	.018	3	1
UCEC	p21 →	+0.232	+2.820	.009	.035	3	1
UCEC	p62 Lck ligand →	+0.533	+3.179	<.001	.010	3	1
UCEC	PKC-a →	+0.393	+3.013	.037	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by ERGIC2 expression — UCEC

Explore this box plot interactively →