ERG28

Across TCGA patient cohorts, ERG28 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERG28-associated genes across cancer lineages are VEGFR2, 4E-BP1, and PRAS40_pT246. Each is linked with ERG28 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERG28-to-partner and partner-to-ERG28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEGFR2 grouped by ERG28-low versus ERG28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERG28→partner) and Y-score (partner→ERG28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VEGFR2 →	+0.404	+2.820	.026	.036	3	1
UCEC	4E-BP1 →	+0.778	+2.837	<.001	.035	2	1
UCEC	PRAS40_pT246 →	+0.234	+2.820	.026	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

VEGFR2 by ERG28 expression — UCEC

Explore this box plot interactively →