ERF

Across TCGA pan-cancer cohorts, ERF mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ERF data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ERF mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ERF expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where ERF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.628	1.000	.024	16	view →
CCRCC	DFS	Quartile	III,IV	0.665	0.277	.008	10	view →
PDAC	OS	Median	IV	0.472	0.962	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ERF–UCEC (OS)

Open the UCEC breakdown →