ERF

Across TCGA patient cohorts, ERF mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERF-associated genes across cancer lineages are 14-3-3_beta, MEK1, and MSH2. Each is linked with ERF in more than 1 cancer types. Because this analysis shows association rather than direction, both ERF-to-partner and partner-to-ERF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ERF-low versus ERF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERF→partner) and Y-score (partner→ERF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.100	-2.308	.016	.006	3	2
UCEC	MEK1 →	+0.444	+2.321	.003	.006	3	2
UCEC	MSH2 →	-0.219	-3.143	.021	.018	3	2
UCEC	Akt_pT308 →	+0.648	+2.459	.012	.019	3	2
UCEC	Rad50 →	-0.232	-1.807	.020	.027	3	2
UCEC	ATM →	-0.465	-1.807	.013	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

14-3-3_beta by ERF expression — UCEC

Explore this box plot interactively →