ERF

Across TCGA cell cohorts, ERF RNA expression is significantly associated with the go_rna of many other GO terms, with 4,427 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ERF-associated GO terms across cancer lineages are Negative regulation of RNA splicing, Positive regulation of intracellular steroid hormone receptor signaling pathway, and mRNA alternative polyadenylation. Each is linked with ERF in more than 13 cancer types. Because this analysis shows association rather than direction, both ERF-to-partner and partner-to-ERF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA splicing grouped by ERF-low versus ERF-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERF→partner) and Y-score (partner→ERF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of RNA splicing →	+0.079	+0.776	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.114	+0.771	<.001	<.001	3	14
BONE	mRNA alternative polyadenylation →	+0.097	+1.141	<.001	<.001	2	14
STOMACH	Negative regulation of calcium ion export across plasma membrane →	+0.090	+1.094	<.001	.007	3	13
BONE	Negative regulation of mRNA processing →	+0.104	+1.026	<.001	<.001	3	13
BONE	Positive regulation of DNA metabolic process →	+0.076	+0.993	.003	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,427 associations by consensus.

Negative regulation of RNA splicing by ERF expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →