ERF

Across TCGA cell cohorts, ERF mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERF-associated genes across cancer lineages are GUCA2A, PRR27, and PRSS58. Each is linked with ERF in more than 1 cancer types. Because this analysis shows association rather than direction, both ERF-to-partner and partner-to-ERF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by ERF-low versus ERF-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERF→partner) and Y-score (partner→ERF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.031	+4.554	<.001	<.001	3	2
LARGE_INTESTINE	PRR27 →	+0.156	+3.376	<.001	.002	3	2
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
CNS	FSHB →	+0.042	+5.321	<.001	.005	3	1
CNS	BPIFB6 →	+0.052	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	RXFP2 →	+0.049	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

GUCA2A by ERF expression — BLOOD_Leukemia

Explore this box plot interactively →