ERF

Across TCGA cell cohorts, ERF mutation is significantly associated with the mutation status of many other genes, with 5,104 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERF-associated genes across cancer lineages are KCNH4, EPHA6, and MAPK8IP3. Each is linked with ERF in more than 5 cancer types. Because this analysis shows association rather than direction, both ERF-to-partner and partner-to-ERF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNH4 grouped by ERF-low versus ERF-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERF→partner) and Y-score (partner→ERF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KCNH4 →	+4.339	+4.339	.009	.009	1	6
PANCREAS	EPHA6 →	+5.115	+5.115	.005	.005	1	5
LUNG_NSCLC_LUAD	MAPK8IP3 →	+5.339	+4.772	.004	.004	1	5
SKIN	RAPGEF2 →	+3.316	+3.906	.004	.004	1	5
BLOOD_Leukemia	ROBO3 →	+3.176	+3.078	.002	.002	1	5
LARGE_INTESTINE	PI4KA →	+2.478	+4.392	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,104 associations by consensus.

KCNH4 by ERF expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →