ERCC8

Across TCGA pan-cancer cohorts, ERCC8 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ERCC8 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ERCC8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ERCC8 expression acts as an unfavorable survival marker.

BRCA, BLCA, and SKCM are the cancer types where ERCC8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.110	0.579	<.001	14	view →
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
SKCM	OS	Median	All	0.362	0.784	.013	12	view →
CESC	DFS	Median	II,III,IV	0.086	0.497	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ERCC8–BRCA (OS)

Open the BRCA breakdown →