ERCC8

Across TCGA patient cohorts, ERCC8 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,241 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ERCC8-associated proteins across cancer lineages are KIF2A, RPL14, and RPS6. Each is linked with ERCC8 in more than 6 cancer types. Because this analysis shows association rather than direction, both ERCC8-to-partner and partner-to-ERCC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC8 versus KIF2A in GBM, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC8→partner) and Y-score (partner→ERCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIF2A →	+0.209	+0.280	<.001	<.001	3	7
BRCA	RPL14 →	-0.383	-0.323	.001	.001	3	5
BRCA	RPS6 →	-0.518	-0.344	<.001	<.001	3	5
PDAC	RASA1 →	+0.215	+0.235	.002	<.001	3	4
UCEC	RNF5 →	+0.416	+0.316	.003	.002	3	4
GBM	RPL7 →	-0.417	-0.328	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,241 associations by consensus.

ERCC8 vs KIF2A — GBM

Explore this scatter interactively →