ERCC8

Across TCGA patient cohorts, ERCC8 protein abundance is significantly associated with the RNA expression of many other genes, with 15,546 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ERCC8-associated genes across cancer lineages are OTUD7A, PHLPP1, and CTSZ. Each is linked with ERCC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERCC8-to-partner and partner-to-ERCC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC8 versus OTUD7A in CCRCC, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC8→partner) and Y-score (partner→ERCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	OTUD7A →	+0.485	+0.262	.001	<.001	3	3
HNSC	PHLPP1 →	+0.546	+0.245	.003	.001	3	3
CCRCC	CTSZ →	-0.754	-0.300	<.001	<.001	3	3
CCRCC	NPL →	-0.673	-0.227	.001	.001	3	3
GBM	B3GALT1 →	+0.843	+0.271	<.001	.002	3	3
BRCA	TIMM9 →	+0.271	+0.274	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,546 associations by consensus.

ERCC8 vs OTUD7A — CCRCC

Explore this scatter interactively →