ERCC8

Across TCGA patient cohorts, ERCC8 mutation is significantly associated with the RNA expression of many other genes, with 1,825 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC8-associated genes across cancer lineages are RN7SL447P, RNU6-389P, and MIR6752. Each is linked with ERCC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERCC8-to-partner and partner-to-ERCC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL447P grouped by ERCC8-low versus ERCC8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC8→partner) and Y-score (partner→ERCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL447P →	+0.154	+4.201	<.001	.002	3	3
COAD	RNU6-389P →	+0.297	+3.280	<.001	.008	3	2
STAD	MIR6752 →	+0.575	+6.400	<.001	.001	3	2
UCEC	NOP10 →	+0.420	+1.938	<.001	.001	3	2
UCEC	BRI3BP →	+0.614	+2.654	<.001	<.001	3	2
UCEC	FICD →	+0.433	+2.177	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,825 associations by consensus.

RN7SL447P by ERCC8 expression — CESC

Explore this box plot interactively →