ERCC8

Across TCGA patient cohorts, ERCC8 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC8-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and PCNA. Each is linked with ERCC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERCC8-to-partner and partner-to-ERCC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ERCC8-low versus ERCC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC8→partner) and Y-score (partner→ERCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.620	+2.135	.003	.010	3	3
UCEC	MEK1 →	+0.327	+2.222	.013	.010	3	2
UCEC	PCNA →	+0.180	+1.925	.020	.005	3	2
UCEC	ATM →	-0.367	-2.584	.024	.010	3	2
UCEC	C-Raf →	+0.143	+1.925	.005	.005	3	2
UCEC	Cyclin-B1 →	+0.629	+3.700	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by ERCC8 expression — UCEC

Explore this box plot interactively →