ERCC8

Across TCGA cell cohorts, ERCC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,859 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERCC8-associated GO terms across cancer lineages are Nucleotide-excision repair, Positive regulation of rRNA processing, and Regulation of chromosome segregation. Each is linked with ERCC8 in more than 12 cancer types. Because this analysis shows association rather than direction, both ERCC8-to-partner and partner-to-ERCC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleotide-excision repair grouped by ERCC8-low versus ERCC8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC8→partner) and Y-score (partner→ERCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nucleotide-excision repair →	+0.072	+0.822	.001	<.001	3	13
OVARY	Positive regulation of rRNA processing →	+0.116	+0.515	.002	.005	3	12
SOFT_TISSUE	Regulation of chromosome segregation →	+0.122	+0.725	<.001	.001	3	12
OVARY	Single strand break repair →	+0.082	+0.760	.002	.002	3	12
BLOOD_Lymphoma	Chromosome localization →	+0.078	+0.816	.002	.001	3	11
BLOOD_Lymphoma	Metaphase chromosome alignment →	+0.085	+0.878	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,859 associations by consensus.

Nucleotide-excision repair by ERCC8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →