ERCC8

Across TCGA cell cohorts, ERCC8 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC8-associated genes across cancer lineages are OR10T2, FAM236A, and ZNF831. Each is linked with ERCC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERCC8-to-partner and partner-to-ERCC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by ERCC8-low versus ERCC8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC8→partner) and Y-score (partner→ERCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10T2 →	+1.158	+4.276	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	2
LARGE_INTESTINE	ZNF831 →	+0.010	+2.688	<.001	.008	3	1
LARGE_INTESTINE	SULT6B1 →	+0.024	+3.240	<.001	.004	3	1
LARGE_INTESTINE	ACSM2A →	+0.034	+2.688	.001	.008	3	1
LARGE_INTESTINE	PRAMEF10 →	+0.346	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR10T2 by ERCC8 expression — BLOOD_Leukemia

Explore this box plot interactively →