ERCC8-AS1

Across TCGA pan-cancer cohorts, ERCC8-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated ERCC8-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ERCC8-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERCC8-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and THCA show a favorable association.

KIRC, ACC, and STAD are the cancer types where ERCC8-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.499	0.708	<.001	96	view →
ACC	OS	Median	All	0.686	0.888	<.001	85	view →
STAD	DFS	Quartile	II,III,IV	0.431	0.688	.005	43	view →
COAD	DFS	Tertile	All	0.659	0.820	<.001	40	view →
SKCM	OS	Tertile	All	0.393	0.283	.004	14	view →
BLCA	OS	Median	All	0.264	0.564	.006	12	view →
UCS	DFS	Median	IV	0.440	0.885	.015	10	view →
THCA	DFS	Median	All	0.956	0.912	.010	7	view →
UCEC	DFS	Tertile	All	0.563	0.677	.027	6	view →
LUSC	OS	Median	II,III,IV	0.790	0.669	.022	5	view →
DLBC	OS	Tertile	II,III,IV	0.563	1.000	.008	4	view →
CHOL	DFS	Median	III,IV	0.133	0.779	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

ERCC8-AS1–KIRC (DFS)

Open the KIRC breakdown →