ERCC6L2

Across TCGA patient cohorts, ERCC6L2 mutation is significantly associated with the RNA expression of many other genes, with 5,270 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC6L2-associated genes across cancer lineages are RNA5SP405, SNORD114-4, and TRBV24OR9-2. Each is linked with ERCC6L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERCC6L2-to-partner and partner-to-ERCC6L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP405 grouped by ERCC6L2-low versus ERCC6L2-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6L2→partner) and Y-score (partner→ERCC6L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	RNA5SP405 →	+0.384	+3.967	.004	.004	3	3
ESCA	SNORD114-4 →	+0.833	+4.300	<.001	.002	3	3
ESCA	TRBV24OR9-2 →	+0.062	+3.967	.004	.004	3	3
UCEC	PDZD8 →	+0.746	+2.126	<.001	<.001	3	3
UCEC	ZDHHC14 →	-0.389	-2.038	<.001	.001	3	3
UCEC	KMT5A →	+0.399	+1.760	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,270 associations by consensus.

RNA5SP405 by ERCC6L2 expression — ESCA

Explore this box plot interactively →