Across TCGA patient cohorts, ERCC6L mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC6L-associated genes across cancer lineages are VHL, EGFR_pY1068, and INPP4B. Each is linked with ERCC6L in more than 2 cancer types. Because this analysis shows association rather than direction, both ERCC6L-to-partner and partner-to-ERCC6L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6L→partner) and Y-score (partner→ERCC6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.837	-1.938	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.257	-1.754	<.001	.001	3	2
UCEC	INPP4B →	-0.309	-1.807	.001	.003	3	2
UCEC	mTOR_pS2448 →	-0.107	-1.372	.018	.017	3	2
UCEC	NDRG1_pT346 →	-0.383	-1.906	.009	.014	3	2
UCEC	ATM →	-0.472	-1.530	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

ERCC6L survival (RNA) · tumor vs normal (RNA) · all ERCC6L data types