Across TCGA cell cohorts, ERCC6L mutation is significantly associated with the RNA expression of many other genes, with 126 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC6L-associated genes across cancer lineages are TSGA13, FCN2, and SPEM1. Each is linked with ERCC6L in more than 1 cancer types. Because this analysis shows association rather than direction, both ERCC6L-to-partner and partner-to-ERCC6L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6L→partner) and Y-score (partner→ERCC6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSGA13 →	+0.058	+4.169	<.001	.008	3	2
LARGE_INTESTINE	FCN2 →	+0.020	+3.192	<.001	.002	3	2
LARGE_INTESTINE	SPEM1 →	+0.073	+2.347	<.001	.007	3	2
LARGE_INTESTINE	SPEM2 →	+0.037	+2.626	.007	.002	3	2
BREAST	TBX5 →	+0.364	+2.906	.001	.007	3	2
BLOOD_Leukemia	A3GALT2 →	+0.029	+4.133	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

Exploration

ERCC6L survival (RNA) · tumor vs normal (RNA) · all ERCC6L data types