Across TCGA patient cohorts, ERCC6 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,845 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ERCC6-associated proteins across cancer lineages are NHLRC2, SEC24A, and SELENOK. Each is linked with ERCC6 in more than 4 cancer types. Because this analysis shows association rather than direction, both ERCC6-to-partner and partner-to-ERCC6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6→partner) and Y-score (partner→ERCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NHLRC2 →	+0.317	+0.545	<.001	<.001	3	5
CCRCC	SEC24A →	-0.286	-0.287	<.001	<.001	3	5
HNSC	SELENOK →	-0.344	-0.460	<.001	<.001	3	5
COAD	SIRT1 →	+0.390	+0.300	.007	.007	3	5
GBM	MACROH2A2 →	+0.763	+0.511	<.001	<.001	3	5
UCEC	TFAM →	+0.411	+0.449	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,845 associations by consensus.

Exploration

ERCC6 survival (RNA) · tumor vs normal (RNA) · all ERCC6 data types