Across TCGA patient cohorts, ERCC6 protein abundance is significantly associated with the RNA expression of many other genes, with 4,403 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ERCC6-associated genes across cancer lineages are CD4, DOCK8, and PMP22. Each is linked with ERCC6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ERCC6-to-partner and partner-to-ERCC6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6→partner) and Y-score (partner→ERCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD4 →	-0.846	-0.363	<.001	<.001	3	3
OV	DOCK8 →	-0.657	-0.315	.005	.006	3	3
BRCA	PMP22 →	-0.841	-0.173	<.001	.002	3	3
OV	FMNL3 →	-0.670	-0.414	.005	<.001	3	3
BRCA	PRICKLE2 →	-0.822	-0.184	<.001	.005	3	3
GBM	NLGN3 →	-0.800	-0.279	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,403 associations by consensus.

Exploration

ERCC6 survival (RNA) · tumor vs normal (RNA) · all ERCC6 data types