Across TCGA patient cohorts, ERCC6 mutation is significantly associated with the RNA expression of many other genes, with 4,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC6-associated genes across cancer lineages are MELK, CENPN, and RRM1. Each is linked with ERCC6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ERCC6-to-partner and partner-to-ERCC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6→partner) and Y-score (partner→ERCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MELK →	+0.591	+1.885	<.001	.001	3	4
UCEC	CENPN →	+0.662	+1.809	<.001	<.001	3	4
UCEC	RRM1 →	+0.726	+2.243	<.001	<.001	3	4
UCEC	RAD51 →	+0.743	+1.974	<.001	<.001	3	4
UCEC	ORC1 →	+0.650	+1.624	<.001	<.001	3	4
UCEC	ZWINT →	+0.614	+1.888	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,015 associations by consensus.

Exploration

ERCC6 survival (RNA) · tumor vs normal (RNA) · all ERCC6 data types