Across TCGA cell cohorts, ERCC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,889 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC6-associated GO terms across cancer lineages are Double-strand break repair via classical nonhomologous end joining, Double-strand break repair via nonhomologous end joining, and Regulation of protein localization to mitochondrion. Each is linked with ERCC6 in more than 18 cancer types. Because this analysis shows association rather than direction, both ERCC6-to-partner and partner-to-ERCC6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6→partner) and Y-score (partner→ERCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Double-strand break repair via classical nonhomologous end joining →	+0.084	+0.880	.002	.004	3	19
BLOOD_Myeloma	Double-strand break repair via nonhomologous end joining →	+0.060	+0.988	.001	<.001	3	14
STOMACH	Regulation of protein localization to mitochondrion →	+0.132	+1.320	<.001	<.001	3	13
BONE	Protein localization to endosome →	+0.170	+0.833	<.001	.001	3	13
SOFT_TISSUE	Vacuolar transport →	+0.058	+1.091	<.001	<.001	3	13
LIVER	Negative regulation of organelle assembly →	+0.074	+1.627	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,889 associations by consensus.

Exploration

ERCC6 survival (RNA) · tumor vs normal (RNA) · all ERCC6 data types