Across TCGA cell cohorts, ERCC6 mutation is significantly associated with the mutation status of many other genes, with 6,496 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC6-associated genes across cancer lineages are FBN3, SOGA1, and MED13. Each is linked with ERCC6 in more than 6 cancer types. Because this analysis shows association rather than direction, both ERCC6-to-partner and partner-to-ERCC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6→partner) and Y-score (partner→ERCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FBN3 →	+3.016	+3.137	<.001	<.001	1	7
BREAST	SOGA1 →	+4.558	+3.442	.003	.003	1	6
BLOOD_Leukemia	MED13 →	+2.499	+2.697	.002	.002	1	6
BLOOD_Leukemia	SMARCA2 →	+2.762	+2.690	.005	.005	1	6
SKIN	ANKRD52 →	+3.655	+4.906	.001	.001	1	6
BLOOD_Leukemia	BPTF →	+2.210	+2.478	.005	.005	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,496 associations by consensus.

Exploration

ERCC6 survival (RNA) · tumor vs normal (RNA) · all ERCC6 data types