ERCC5

Across TCGA pan-cancer cohorts, ERCC5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ERCC5 data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher ERCC5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERCC5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, ESCA, and UCEC are the cancer types where ERCC5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.145	0.542	<.001	18	view →
ESCA	DFS	Median	All	0.102	0.536	<.001	18	view →
UCEC	DFS	Median	All	0.954	0.824	.009	18	view →
DLBC	OS	Median	All	0.054	0.842	<.001	6	view →
LUAD	OS	Median	II,III,IV	0.150	0.677	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ERCC5–OV (DFS)

Open the OV breakdown →