ERCC5

Across TCGA patient cohorts, ERCC5 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,080 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ERCC5-associated proteins across cancer lineages are ARHGEF7, TPP2, and NAXD. Each is linked with ERCC5 in more than 7 cancer types. Because this analysis shows association rather than direction, both ERCC5-to-partner and partner-to-ERCC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC5 versus ARHGEF7 in GBM, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC5→partner) and Y-score (partner→ERCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGEF7 →	+0.328	+0.266	<.001	<.001	3	8
BRCA	TPP2 →	+0.275	+0.430	<.001	<.001	3	6
GBM	NAXD →	+0.357	+0.229	<.001	.002	3	6
LSCC	STK24 →	+0.307	+0.488	<.001	<.001	3	5
LSCC	CUL4A →	+0.316	+0.270	.008	.003	3	5
LSCC	ELF1_S187 →	+0.595	+0.487	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,080 associations by consensus.

ERCC5 vs ARHGEF7 — GBM

Explore this scatter interactively →