ERCC5

Across TCGA patient cohorts, ERCC5 mutation is significantly associated with the RNA expression of many other genes, with 7,209 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC5-associated genes across cancer lineages are CEP76, VPS53, and PCLAF. Each is linked with ERCC5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ERCC5-to-partner and partner-to-ERCC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP76 grouped by ERCC5-low versus ERCC5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC5→partner) and Y-score (partner→ERCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEP76 →	+0.548	+2.933	<.001	<.001	3	4
UCEC	VPS53 →	+0.389	+1.783	<.001	<.001	3	4
UCEC	PCLAF →	+0.643	+1.772	<.001	<.001	3	4
COAD	VAPA →	+0.520	+4.013	<.001	<.001	3	3
UCEC	AAGAB →	+0.534	+2.147	<.001	<.001	3	3
UCEC	OIP5 →	+0.894	+2.513	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,209 associations by consensus.

CEP76 by ERCC5 expression — COAD

Explore this box plot interactively →