ERCC5

Across TCGA cell cohorts, ERCC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,970 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERCC5-associated GO terms across cancer lineages are Ribosomal protein import into nucleus, Cilium or flagellum-dependent cell motility, and Cilium-dependent cell motility. Each is linked with ERCC5 in more than 12 cancer types. Because this analysis shows association rather than direction, both ERCC5-to-partner and partner-to-ERCC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal protein import into nucleus grouped by ERCC5-low versus ERCC5-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC5→partner) and Y-score (partner→ERCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Ribosomal protein import into nucleus →	+0.071	+0.651	<.001	<.001	3	13
STOMACH	Cilium or flagellum-dependent cell motility →	-0.087	-0.952	.001	.002	3	11
STOMACH	Cilium-dependent cell motility →	-0.087	-0.952	.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of hematopoietic stem cell differentiation →	+0.124	+0.789	<.001	<.001	3	11
PANCREAS	Positive regulation of translational initiation in response to stress →	+0.143	+0.819	.001	.002	2	12
BLOOD_Leukemia	Nucleotide-excision repair, DNA gap filling →	+0.092	+0.708	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,970 associations by consensus.

Ribosomal protein import into nucleus by ERCC5 expression — CNS

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