ERCC4

Across TCGA patient cohorts, ERCC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,777 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ERCC4-associated proteins across cancer lineages are THUMPD1, ERCC1, and PARN. Each is linked with ERCC4 in more than 6 cancer types. Because this analysis shows association rather than direction, both ERCC4-to-partner and partner-to-ERCC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC4 versus THUMPD1 in BRCA, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC4→partner) and Y-score (partner→ERCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THUMPD1 →	+0.376	+0.533	<.001	<.001	3	7
OV	ERCC1 →	+0.583	+0.629	<.001	<.001	3	6
OV	PARN →	+0.422	+0.784	<.001	<.001	3	5
LSCC	TCEAL4 →	+0.406	+0.449	<.001	<.001	3	5
BRCA	LCMT1 →	+0.435	+0.523	<.001	.003	3	5
LUAD	RPL26 →	-0.573	-0.446	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,777 associations by consensus.

ERCC4 vs THUMPD1 — BRCA

Explore this scatter interactively →