ERCC4

Across TCGA patient cohorts, ERCC4 protein abundance is significantly associated with the RNA expression of many other genes, with 6,012 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ERCC4-associated genes across cancer lineages are LYRM1, PARN, and MIR762HG. Each is linked with ERCC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both ERCC4-to-partner and partner-to-ERCC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC4 versus LYRM1 in BRCA, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC4→partner) and Y-score (partner→ERCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LYRM1 →	+0.778	+0.292	<.001	<.001	3	5
BRCA	PARN →	+0.551	+0.277	<.001	<.001	3	5
BRCA	MIR762HG →	+0.508	+0.261	.001	.001	3	5
BRCA	CD2BP2-DT →	+0.987	+0.265	.001	<.001	3	5
BRCA	POLR3E →	+0.575	+0.215	.001	.006	3	5
LSCC	ZNF263 →	+0.567	+0.240	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,012 associations by consensus.

ERCC4 vs LYRM1 — BRCA

Explore this scatter interactively →