ERCC4

Across TCGA patient cohorts, ERCC4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC4-associated genes across cancer lineages are Notch1, Chk2, and eIF4E. Each is linked with ERCC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERCC4-to-partner and partner-to-ERCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ERCC4-low versus ERCC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC4→partner) and Y-score (partner→ERCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.131	+1.884	<.001	.001	3	3
UCEC	Chk2 →	-0.210	-1.722	.001	<.001	3	3
UCEC	eIF4E →	+0.147	+2.713	.011	.003	3	2
UCEC	MSH2 →	-0.296	-2.111	<.001	<.001	3	2
UCEC	MSH6 →	-0.275	-1.584	.002	.007	3	2
UCEC	SLC1A5 →	-0.237	-1.584	.048	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Notch1 by ERCC4 expression — UCEC

Explore this box plot interactively →