ERCC4

Across TCGA cell cohorts, ERCC4 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC4-associated genes across cancer lineages are KRTAP4-11, FSHB, and KRTAP10-2. Each is linked with ERCC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERCC4-to-partner and partner-to-ERCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-11 grouped by ERCC4-low versus ERCC4-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC4→partner) and Y-score (partner→ERCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KRTAP4-11 →	+0.015	+4.285	<.001	.007	3	1
BLOOD_Leukemia	FSHB →	+0.005	+5.569	<.001	.001	3	1
BLOOD_Leukemia	KRTAP10-2 →	+0.060	+4.152	.003	.009	3	1
BLOOD_Leukemia	KCNU1 →	+0.049	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR5M1 →	+0.015	+5.569	<.001	.001	3	1
LARGE_INTESTINE	SLC39A12 →	+0.077	+3.700	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

KRTAP4-11 by ERCC4 expression — STOMACH

Explore this box plot interactively →