ERCC3

Across TCGA pan-cancer cohorts, ERCC3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ERCC3 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ERCC3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ERCC3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where ERCC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.967	0.723	.002	25	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	12	view →
HNSC	OS	Quartile	All	0.176	0.964	.017	12	view →
LUAD	OS	Tertile	All	0.531	0.832	.007	11	view →
OV	DFS	Median	All	0.942	0.655	.011	8	view →
UCEC	DFS	Tertile	All	0.785	0.940	.027	2	view →
GBM	DFS	Quartile	All	0.464	0.238	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ERCC3–LSCC (OS)

Open the LSCC breakdown →