ERCC3

Across TCGA patient cohorts, ERCC3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,816 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ERCC3-associated genes across cancer lineages are KIF18A, HMGA1, and CDC6. Each is linked with ERCC3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ERCC3-to-partner and partner-to-ERCC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC3 versus KIF18A in HNSC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC3→partner) and Y-score (partner→ERCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KIF18A →	+0.957	+0.175	<.001	<.001	3	6
LSCC	HMGA1 →	+1.108	+0.319	<.001	<.001	3	6
LUAD	CDC6 →	+1.105	+0.170	<.001	<.001	3	6
HNSC	GINS1 →	+0.793	+0.173	<.001	<.001	3	5
BRCA	MTFR2 →	+0.721	+0.217	.001	<.001	3	5
HNSC	SPC25 →	+0.693	+0.172	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,816 associations by consensus.

ERCC3 vs KIF18A — HNSC

Explore this scatter interactively →