ERCC3

Across TCGA patient cohorts, ERCC3 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC3-associated genes across cancer lineages are eIF4E, PCNA, and ERK2. Each is linked with ERCC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERCC3-to-partner and partner-to-ERCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ERCC3-low versus ERCC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC3→partner) and Y-score (partner→ERCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.221	+2.263	.001	<.001	3	3
UCEC	PCNA →	+0.300	+2.643	<.001	<.001	3	3
UCEC	ERK2 →	+0.182	+2.115	.004	.016	3	2
UCEC	FOXO3a_pS318_S321 →	-0.103	-1.575	.011	.017	3	2
COAD	GAPDH →	+0.719	+3.178	.003	.010	3	2
UCEC	MAPK_pT202_Y204 →	-0.434	-2.415	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

eIF4E by ERCC3 expression — UCEC

Explore this box plot interactively →