ERCC3

Across TCGA cell cohorts, ERCC3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC3-associated genes across cancer lineages are KRTAP9-7, KRTAP9-6, and SYT10. Each is linked with ERCC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERCC3-to-partner and partner-to-ERCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-7 grouped by ERCC3-low versus ERCC3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC3→partner) and Y-score (partner→ERCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP9-7 →	+0.073	+5.643	<.001	.002	3	1
LUNG_SCLC	KRTAP9-6 →	+0.136	+5.643	<.001	.002	3	1
LARGE_INTESTINE	SYT10 →	+0.199	+3.196	<.001	.007	3	1
LARGE_INTESTINE	RNF175 →	+0.132	+3.736	<.001	.004	3	1
LARGE_INTESTINE	SMCP →	+0.021	+3.632	<.001	.003	3	1
LARGE_INTESTINE	FAM162B →	+0.113	+3.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

KRTAP9-7 by ERCC3 expression — LUNG_SCLC

Explore this box plot interactively →