ERCC2

Across TCGA patient cohorts, ERCC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,078 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ERCC2-associated proteins across cancer lineages are PUS7, SF3B1, and MEST. Each is linked with ERCC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ERCC2-to-partner and partner-to-ERCC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC2 versus PUS7 in LSCC, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC2→partner) and Y-score (partner→ERCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PUS7 →	+0.404	+0.432	<.001	<.001	3	5
GBM	SF3B1 →	+0.216	+0.344	<.001	<.001	3	5
OV	MEST →	+0.699	+0.620	.002	.001	3	5
UCEC	UTP18 →	+0.274	+0.584	<.001	<.001	3	5
LSCC	ZMYM2 →	+0.446	+0.486	<.001	<.001	3	5
GBM	XRCC1 →	+0.301	+0.304	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,078 associations by consensus.

ERCC2 vs PUS7 — LSCC

Explore this scatter interactively →