ERCC2

Across TCGA patient cohorts, ERCC2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC2-associated genes across cancer lineages are Cyclin-E1, ATM, and MEK1. Each is linked with ERCC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERCC2-to-partner and partner-to-ERCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E1 grouped by ERCC2-low versus ERCC2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC2→partner) and Y-score (partner→ERCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Cyclin-E1 →	+0.249	+1.485	.014	.049	3	3
UCEC	ATM →	-0.564	-1.765	<.001	.014	3	3
UCEC	MEK1 →	+0.542	+3.321	<.001	<.001	3	2
BLCA	c-Kit →	-0.302	-3.000	.001	<.001	3	2
UCEC	N-Ras →	-0.105	-2.302	.018	.034	3	2
UCEC	Rad50 →	-0.248	-1.765	.006	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Cyclin-E1 by ERCC2 expression — BLCA

Explore this box plot interactively →