ERCC2

Across TCGA cell cohorts, ERCC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,434 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC2-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Regulation of hippo signaling, and Negative regulation of hippo signaling. Each is linked with ERCC2 in more than 15 cancer types. Because this analysis shows association rather than direction, both ERCC2-to-partner and partner-to-ERCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by ERCC2-low versus ERCC2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC2→partner) and Y-score (partner→ERCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.094	+0.945	.001	<.001	3	16
BONE	Regulation of hippo signaling →	+0.104	+1.160	<.001	<.001	3	14
BREAST	Negative regulation of hippo signaling →	+0.112	+1.184	<.001	<.001	3	14
PANCREAS	Transcription-coupled nucleotide-excision repair →	+0.094	+0.869	<.001	<.001	3	14
STOMACH	Transcription initiation at RNA polymerase I promoter →	+0.116	+1.282	.001	.006	2	15
STOMACH	Microtubule polymerization or depolymerization →	+0.109	+1.160	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,434 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by ERCC2 expression — BREAST

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