ERCC2

Across TCGA cell cohorts, ERCC2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC2-associated genes across cancer lineages are OR10R2, GSTA3, and TSPAN16. Each is linked with ERCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERCC2-to-partner and partner-to-ERCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by ERCC2-low versus ERCC2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC2→partner) and Y-score (partner→ERCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR10R2 →	+0.018	+3.786	<.001	.004	3	1
SKIN	GSTA3 →	+0.849	+3.196	<.001	.007	3	1
LUNG_NSCLC_LUAD	TSPAN16 →	+0.077	+4.479	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.031	+3.215	.007	.007	3	1
LUNG_NSCLC_LUAD	KRTAP9-3 →	+0.010	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	INSRR →	+0.048	+4.142	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR10R2 by ERCC2 expression — PANCREAS

Explore this box plot interactively →