ERCC2

Across TCGA cell cohorts, ERCC2 mutation is significantly associated with the mutation status of many other genes, with 3,984 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC2-associated genes across cancer lineages are ASXL1, NOVA1, and KMT2B. Each is linked with ERCC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ERCC2-to-partner and partner-to-ERCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASXL1 grouped by ERCC2-low versus ERCC2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC2→partner) and Y-score (partner→ERCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ASXL1 →	+3.321	+3.035	.008	.008	1	5
UPPER_AERODIGESTIVE_TRACT	NOVA1 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	KMT2B →	+4.392	+4.954	.008	.008	1	4
SKIN	FBXL7 →	+3.321	+3.035	.008	.008	1	4
LUNG_NSCLC_LUAD	CASZ1 →	+3.303	+3.478	.006	.006	1	4
LARGE_INTESTINE	HELB →	+2.392	+3.050	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,984 associations by consensus.

ASXL1 by ERCC2 expression — SKIN

Explore this box plot interactively →