ERCC1

Across TCGA patient cohorts, ERCC1 RNA expression is significantly associated with the RNA expression of many other genes, with 18,670 significant associations in total. ACC shows the largest number of these associations.

The most reproducible ERCC1-associated genes across cancer lineages are ERCC2, INAFM1, and SNRNP70. Each is linked with ERCC1 in more than 32 cancer types. Because this analysis shows association rather than direction, both ERCC1-to-partner and partner-to-ERCC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC1 versus ERCC2 in ACC, with a Pearson correlation of 0.78.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC1→partner) and Y-score (partner→ERCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	ERCC2 →	+0.961	+0.920	<.001	<.001	3	33
ACC	INAFM1 →	+1.589	+1.080	<.001	<.001	3	33
ACC	SNRNP70 →	+1.054	+1.062	<.001	<.001	3	32
ACC	RPS19 →	+1.471	+1.065	<.001	<.001	3	32
DLBC	HSPBP1 →	+1.083	+0.724	<.001	<.001	3	32
ACC	RPS11 →	+1.301	+1.139	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,670 associations by consensus.

ERCC1 vs ERCC2 — ACC

Explore this scatter interactively →