ERCC1

Across TCGA patient cohorts, ERCC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,511 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ERCC1-associated proteins across cancer lineages are ARHGAP35, HNRNPUL1, and PAFAH1B3. Each is linked with ERCC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ERCC1-to-partner and partner-to-ERCC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC1 versus ARHGAP35 in OV, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC1→partner) and Y-score (partner→ERCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGAP35 →	+0.398	+0.709	<.001	<.001	3	6
OV	HNRNPUL1 →	+0.391	+0.545	.006	<.001	3	6
CCRCC	PAFAH1B3 →	+0.359	+0.344	<.001	<.001	3	5
OV	PPP1R13L →	+0.459	+0.475	<.001	<.001	3	4
OV	LRPPRC →	-0.387	-0.395	<.001	<.001	3	4
OV	MMP2 →	+0.697	+0.446	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,511 associations by consensus.

ERCC1 vs ARHGAP35 — OV

Explore this scatter interactively →